The 7 Life-Changing Reasons Why Alcohol and Antidepressants Should Not Be Mixed - Depression is a debilitating mood disorder that is most effectively treated with a combination of medication and therapy. Antidepressants help many people manage their symptoms, but they come with risks and side effects. Drinking while on these medications poses a number of problems, from more severe side effects to addiction and even death. It is never recommended to use alcohol while on antidepressants. If you are having a hard time stopping drinking, seek professional support.

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